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bqj6clt5aar
4 days ago
Actor Joe Manganiello spent seven years battling chronic autoimmune issues in secret.
In his new memoir, he shares how he's recovering, including enlisting a shaman to take him floating.
He shared his health habits with Business Insider, including a testosterone-free workout strategy.
For seven years, actor Joe Manganiello lived in a world of secret pain. In his new book, "Bloodlines," he describes it as a "10-out-of-10 pain" that felt like "someone was raking my intestines with a metal wire grill brush."
From the outside, things looked great. He'd just retired his ****** le as People's "hottest bachelor alive," and was newly wed to actress Sofía Vergara. He was looking forward to playing what he considered the role of a lifetime, having just been cast as a villainous "Deathstroke" in Ben Affleck's new "Batman" movie (later canceled).

#secret #including #insider
limoyzvvimitaso6004
5 days ago
Kevin McEnroe has been sober for seven years and shares his story on his Substack newsletter Serenity Side Down
He looks back on his family saga, including when he became mom Tatum O'Neal's medical proxy after her 2020 stroke. "In helping her, I started to believe I could become a better man."
McEnroe discusses his family's recovery journey and says of his mom, "The fact we're both such bad alcoholics makes us closer because she can be honest with me."
Kevin McEnroe had been in drug rehab for several months when his sister Emily called him in May 2020 about their mom, Tatum O'Neal.
"She'd had a stroke and was in a coma and might not make it," Kevin recalls. "She had overdosed again. I spent the next month fielding calls about her progress — checking if she's alive. I had to show up and be there for her. It was you need to do this, and I did."

#tatum #substack #serenity #down
stompfxpillow
10 days ago
KUALA LUMPUR, Malaysia (AP) — Defending champion and world No. 4-ranked Miyu Yamashita shot a 6-under 66 Friday to take a two-stroke lead after two rounds of the LPGA Tour's Maybank Classic.
The 2025 Women's British Open winner had a two-round total of 13-under 131 on the Kuala Lumpur Golf and Country Club course. She won last year's Malaysian tournament after a three-way playoff.
Julia Lopez Ramirez birdied three of her final four holes for a 66 and was tied for second with Pauline Roussin-Bouchard, who led by a stroke after the first round.
"Try to keep your mind cool and your body hydrated in these conditions," Lopez Ramirez said of her preparations for the weekend in the usual high humidity in Kuala Lumpur.
A Lim Kim had the round of the day, a 64, and was in fourth place, three strokes behind Yamashita.

#round #lopez #malaysia
surtu_ge_bi_zuveso_k
10 days ago
TOMARATA, New Zealand (AP) — Defending champion Fifa Laopakdee of Thailand salvaged a 1-over 71 in strong wind Friday in the Asia-Pacific Amateur Championship to take a two-stroke lead into the weekend at Te Arai Links.
A day after opening with an 8-under 63, Laopakdee began his morning round on the seaside layout bogey-bogey-birdie-bogey-bogey in 35 mph wind. The Arizona State senior also bogeyed the 10th, then birdied Nos. 12, 13 and 17.
"I had a 5‑footer two holes in a row and the ball just snapped 90 degrees," Laopakdee said. "I aimed a foot left from 5 feet and it went like 3 feet right. It's pretty tricky. Overall, it was a grind out there and I would take 7 under for the first two rounds."
The winner will receive spots in the Masters and British Open. Last year in Dubai, Laopakdee won the third hole of a playoff to become the first Thai champion in event history.
Three players from New Zealand followed on the leaderboard. Cooper Moore (70) was second at 5 under, Ryan Xie (71) was 4 under, and Zack Swanwic (67) 3 under. Kaito Sato of ****** an was 2 under after a 72.

#first #defending
packEt
10 days ago
VALLARTA, Mexico — Karl Vilips used two long bridie streaks to take the first-round lead Thursday in the Mexico Open, the first of two straight PGA Tour events in the country.
Vilips shot a 9-under 62 in the afternoon round on the Vidanta Vallarta layout, making five straight birdies on Nos. 11-15 on his opening nine and finishing with four in a row. In between, he had another birdie and a bogey.
The 25-year-old Australian pointed to his driver.
"Had it on a string for the first nine," Vilips said. "Got a little loose in the middle and got it back on course toward the end of the round. It was lift, clean and place today so being in the fairway was a must for me and I took advantage of those drives that I hit."
Kensai Hirata of ***** an was a stroke back, and Ben Griffin was at 64 with Marco Penge, Garrick Higgo and Jeffrey Kang.

#first #nine #thursday
mlasenmohacurob309
10 days ago
Kate Douglass tied a world record, while Katharine Berkoff and Van Mathias broke their first individual world records at USA Swimming's World Short Course Championships Trials in Westmont, Illinois, on Thursday.
Douglass tied training partner Gretchen Walsh's world record in the 50m freestyle. Berkoff broke the 50m backstroke record, and then Mathias swam the fastest short course 100m **** troke in history.
They made the team for the World Short Course Championships in Beijing's Water Cube from Dec. 1-6.
Short course meets are held in 25-meter pools rather than 50-meter pools (long course) used at the Olympics and other major meets in the summer.
SWIMMING: Full Results | Broadcast Schedule

#World #course #tied
wegzzppkbytyuuv
10 days ago
VALLARTA, Mexico (AP) — Karl Vilips used two long bridie streaks to take the first-round lead Thursday in the Mexico Open, the first of two straight PGA Tour events in the country.
Vilips shot a 9-under 62 in the afternoon round on the Vidanta Vallarta layout, making five straight birdies on Nos. 11-15 on his opening nine and finishing with four in a row. In between, he had another birdie and a bogey.
The 25-year-old Australian pointed to his driver.
"Had it on a string for the first nine," Vilips said. "Got a little loose in the middle and got it back on course toward the end of the round. It was lift, clean and place today so being in the fairway was a must for me and I took advantage of those drives that I hit."
Kensai Hirata of ******* an was a stroke back, and Ben Griffin was at 64 with Marco Penge, Garrick Higgo and Jeffrey Kang.

#vallarta #Mexico #straight #back
l5tsbdeuts
10 days ago
England signed off their campaign in the Pakistan ODI Tri-Series with a 55-run victory over Sri Lanka, riding on Ben Duckett's magnificent 167 before Liam Dawson's four-wicket haul derailed the chase at Gaddafi Stadium in Lahore on Thursday.

Asked to bat first after Sri Lanka won the toss and elected to field, England piled up 386/5 in 50 overs, registering the highest ODI total at the Lahore venue. Duckett led the charge with a commanding 132-ball knock, while Tom Banton and captain Harry Brook made valuable contributions to keep the scoreboard moving.

Sri Lanka put up a spirited fight in reply, with Avishka Fernando, Kusal Mendis and Pavan Rathnayake scoring half-centuries. However, Dawson's spell of 4/49 broke the backbone of their middle order as the visitors were bowled out for 331 in 45.1 overs.
Duckett provided the foundation for England's imposing total with an innings of 167 off 132 deliveries. The left-hander combined patience with attacking strokeplay, setting the tone for a commanding batting performance.

He shared an opening partnership of 163 runs with Banton, who contributed 74 off 75 ****** . The stand gave England early control before Duckett continued to accelerate through the middle overs.

Captain Brook then joined the charge, helping England add another 107 runs in a brisk partnership with Duckett. The substantial contributions at the top ensured England maintained momentum throughout the innings and finished with 386/5.

The total surpassed Pakistan's 375/3 against Zimbabwe in 2015 to become the highest ODI score recorded at Gaddafi Stadium.
Sri Lanka needed a strong start to chase down the daunting target and found contributions from Fernando, Mendis and Rathnayake, who all registered half-centuries. Their efforts kept the chase alive, but England continued to find breakthroughs at crucial moments.

Dawson proved particularly effective in the middle overs, finishing with figures of 4/49 from his 10 overs. His spell disrupted Sri Lanka's progress and left the lower order with too much to do.

With the required rate climbing and wickets falling, Sri Lanka eventually folded for 331 in 45.1 overs. Sam Curran claimed the final wicket, dismissing Malinga to complete England's victory.
The 55-run victory gave England a positive finish to their campaign in Pakistan, ending their winless run in the country. However, the result did not alter the tournament's final lineup, with Sri Lanka and Pakistan having already secured qualification for the tri-series final.

#duckett
FNchufh6oVpec
21 days ago
Seeking a route back to winning ways after a stunning 4-3 home loss to Club Brugge in midweek Champions League action, Inter head to Stadio Renato Dall'Ara to face Bologna on Saturday. Despite another disappointing result in Europe, the reigning Serie A holders are leading the way in the domestic championship after six rounds.
Except for a dramatic 2-2 draw against Roma on the stroke of the international break, Cristian Chivu's charges have won all five remaining league fixtures this season, including a 3-0 rout of Parma last weekend. However, there's no room for complacency, as they sit level on points with early surprise package Lazio ahead of Saturday's kickoff.
In stark contrast, Bologna have endured a rough start to the season, picking up just two points from the opening five matchdays (D2, L3). It sent a signal to the club that it was time for new boss Domenico Tedesco to go, with Raffaele Palladino taking his place in the dugout just before the international break. The change paid off quickly as the Rossoblu eked out a 2-1 win at Lecce on the Italian's road debut last time out.
Buoyed by last weekend's triumph, Bologna fans are looking forward to Inter's visit, knowing the Nerazzurri have only won one of the last five Serie A meetings between the sides (D2, L2). Away from the pitch, fans looking to protect their online privacy while streaming matches or browsing football coverage can explore VPN services. With these, you can add a dedicated IP to your Private Internet Access plan, giving you an IP address reserved for your use rather than shared with other VPN users.
Without further ado, let's see how this clash could unfold.

#bologna #five #season #points
deeply
21 days ago
Catherine Breed completed a never-before-attempted 900-mile open-water swim along the entire California coast on Sunday.
The 33-year-old, record-setting marathon swimmer from Mill Valley battled chilly, unpredictable Pacific waters for four months. She began the unprecedented expedition at the Oregon border on July 1, and expected to reach Mexican waters in November. Breed finished ahead of schedule.
"For months, I measured my world in the next few miles," Breed said. "Every message from someone following along, every person who came out to cheer, helped me get back in the water."
Along the way, Breed swam past the Golden Gate Bridge, the kelp forests of the Monterey Bay and around Point Conception near Santa Barbara, averaging more than 10 miles a day through notoriously rugged waters. Fans following along on social media and gathering at meeting points celebrated each stroke.
The marathon swim project, dubbed "Swim California," was a complex team operation. In the water, a pacer tossed Breed protein shakes in a thermos for sustenance. Breed and the crew accompanying her in a 52-foot sailboat made land each night before returning to the spot she left off. At times, they were forced to wait for suitable weather to advance through the coast's most remote stretches.

#along
pd_ehdg
1 month ago
Valerie Bertinelli fired back at "haters" after posting a tribute to her ex-husband, Eddie Van Halen, on the anniversary of his death.
On Tuesday, October 6, the One Day at a Time and Hot in Cleveland actress, 66, took to Instagram with a video message for followers.
"Strap in haters, let's go for a little ride," she captioned the update, alongside emojis of a hand flashing a peace sign, a white heart, and red lips.
In the video, she shook her head and pointed out, "It does not take long for me to get a lot of pushback when I post a picture of me and Ed. It used to really bother me. It does not. Not any longer because I learned a lot."
Van Halen died at 65 in 2020, following a stroke and battles with lung cancer and throat cancer. He and Bertinelli were married from 1981 to 2007; during that time they welcomed a son, Wolfgang Van Halen, 35.

#bertinelli
0dash
1 month ago
Heidi Klum just brought a very special plus-one to Paris Fashion Week, and the mother-daughter duo is turning heads. The supermodel, 53, stepped out with her youngest child, 16-year-old daughter Lou, for the Vivienne Westwood show. It was the teen's Fashion Week debut, and she proved that she's been taking notes from her stylish mom. The pair coordinated in chic peplum silhouettes and towering platforms.
Heidi Klum and daughter Lou coordinated in peplum looks at the Vivienne Westwood show. Lou, whose dad is singer Seal, usually stays out of the spotlight, which makes this sweet outing even more special. A video from the event shows the two posing side by side in front of a white backdrop splashed with bold orange and red brushstrokes. They look relaxed, happy, and completely in sync.
Heidi went for a glamorous all-white moment. Her ivory satin blazer features a deep plunging neckline, sculpted shoulders, and a single gold ******* on at the waist. She paired it with a matching floor-length satin skirt that skimmed the ground. The model mom finished the look with a sparkling statement necklace and her golden blonde waves styled loose and tousled.
Lou, on the other hand, brought a warm and earthy twist. The teen wore a ******* on-front, corset-style mini dress in a washed brown print. The fitted bodice features thin straps and a scooped neckline, while the flared peplum waist adds a playful touch of movement. The design is a perfect nod to Westwood's famous love for dramatic corsetry and tailoring. She accessorized with a gold bangle and let her dark, voluminous curls fall naturally around her shoulders.
The most eye-catching part of both outfits is the footwear. Lou towers in patterned platform sandals with ankle straps, done in rich brown and red tones that match her dress. Heidi's blue platform shoes peek out from beneath her skirt in a closing shot, adding a fun pop of color to her neutral outfit.

#heidi #klum
coo_madly0885
1 month ago
Jim Bakker, who along with his first wife Tammy Faye built an evangelical empire around the hugely successful "The PTL Club" TV show, only to lose it all over a ****** scandal and financial crimes, has died. He was 86.
Bakker died Monday, his second wife, Lori Bakker, said in a statement. His cause of death was not immediately clear.
"He was a pioneer of Christian television, but to me, he was my husband, my best friend, and the man I was honored to walk beside through so many seasons of life and ministry," she said.
The pair lived near the Missouri entertainment town of Branson and filmed their TV show "The Jim Bakker Show" there since it launched in 2003. Bakker suffered a stroke in 2020.
But it was another evangelical program that made Jim and his first wife Tammy Faye Bakker cultural icons — so much so that they were often skewered in the 1980s and 1990s by late-night comedians and parodied on "Saturday Night Live." A theatrical movie on their lives, "The Eyes of Tammy Faye," was released in September 2021.

#show
com0tMiLDly_26
1 month ago
Isaiah Washington is opening up about a loss he's been keeping private for more than a year. On October 3, the Grey's Anatomy alum revealed that his wife of 29 years, Jenisa Marie Garland-Washington, died in June 2025 after suffering a massive hemorrhagic stroke.
They met in 1995 and got married the following year (@ Getty)
The 63-year-old shared the news 16 months after Garland's death, explaining that the decision to remain silent was largely rooted in the kind of person his wife was.
"Yes... the rumors are true," the actor began in an Instagram post alongside a photo of Garland. He went on to reveal that she suddenly collapsed on May 31, 2025, before dying nine days later on June 9. "It came as a huge shock to our entire family," Washington wrote, explaining that Garland "succumbed to a massive hemorrhagic stroke and never recovered."
He then offered advice, saying, "Listen, y'all…some headaches are not just headaches or migraines; they can be much worse and a warning sign. Get a brain scan if you can and take those headaches seriously."

#garland
dusty4567
1 month ago
Former Grey's Anatomy star Isaiah Washington has confirmed that his wife of 29 years, Jenisa Marie Garland, died over a year ago.
"Yes...the rumors are true," Washington wrote in an Instagram post Saturday. He explained that Garland, a former fashion designer, collapsed "suddenly" on May 31, 2025, and died June 9.
"It came as a huge shock to me and our entire family," the 63-year-old actor wrote. "She succumbed to a massive hemorrhagic stroke and never recovered."
He then warned his followers to pay attention to their bodies. "Listen, y'all …some headaches are not just headaches or migraines, they can be much worse and a warning sign. Get a brain scan if you can and take those headaches seriously."
"She has been gone 16 months now, but she left 3 incredibly amazing children behind to continue her legacy. I don't know if this is an appropriate post, because Jenisa Washington was extremely private, but I guess I just have to be reprimanded from her on the other side," he said.

#former #post
fL5xPull
1 month ago
Isaiah Washington confirms the sudden death of his wife, Jenisa Garland, in 2025.
He said the loss came as "a huge shock to me and our entire family."
Washington is best known for his work on Grey's Anatomy, but retired from acting in 2023.
Isaiah Washington is speaking out on the unexpected death of his wife of 29 years.
The Grey's Anatomy alum's wife, Jenisa Garland, died in May 2025, after collapsing suddenly. According to Washington, Garland suffered a massive hemorrhagic stroke and died nine days later. She was 59.

#garland
u9X7ejL
1 month ago
Oct. 5 (UPI) -- Grey's Anatomy actor Isaiah Washington has announced the death of his wife, Jenisa Washington.
Washington, who played Dr. Preston Burke on Grey's Anatomy, said in an Instagram post over the weekend that Jenisa, his wife of 29 years, died June 9, 2025, after she "collapsed suddenly" that May.
"It came as a huge shock to me and our entire family. She succumbed to a massive hemorrhagic stroke and never recovered," the star wrote.
"She has been gone 16 months now, but she left 3 incredibly amazing children behind to continue her legacy. I don't know if this is an appropriate post, because Jenisa Washington was extremely private, but I guess I just have to be reprimanded from her on the other side," he added.
Washington encouraged others to take headaches and migraines seriously and to possibly investigate further because "they can be much worse and a warning sign."

#preston #burke #june
blink24
1 month ago
Isaiah Washington announced in an Oct. 3 Instagram post that his wife, Jenisa Garlandcollapsed suddenly and died in May 2025 after suffering a hemorrhagic stroke
The retired actor urged followers to take headaches seriously and seek medical attention if they persist
Washington and Garland shared three children and had been married for 29 years
Isaiah Washington has announced the death of his wife, Jenisa Garland, a year after her passing.
The former Grey's Anatomy star, 63, shared in an Instagram post on Saturday, Oct. 3, that his wife, Jenisa Garland, died after suffering a "massive hemorrhagic stroke" on June 9, 2025.

#isaiah #post #died #suffering
wOlf2MBeR_72
1 month ago
Isaiah Washington has broken his silence on the "sudden" death of his wife, Jenisa Garland, last year.
Returning to Instagram on Sunday, the former Grey's Anatomy actor announced that Garland passed away on 9 June 2025 after suffering a "massive haemorrhagic stroke".
"Yes...the rumors are true," he began. "My dear wife of 29 years collapsed suddenly on May 31, 2025 and passed away on June 9, 2025. It came as a huge shock to me and our entire family. She succumbed to a massive hemorrhagic stroke and never recovered."
Washington went on to urge followers to make an appointment with their doctor if they are experiencing headaches.
"Listen, y'all...some headaches are not just headaches or migraines, they can be much worse and a warning sign. Get a brain scan if you can and take those headaches seriously. She has been gone 16 months now, but she left 3 incredibly amazing children behind to continue her legacy," the 63-year-old continued.
Washington and Garland married in 1996.

#garland #wife #stroke
u9X7ejL
1 month ago
"Grey's Anatomy" star Isaiah Washington has shared the "huge shock" his family experienced with his wife's sudden death.
In addressing the speculations concerning his family life, Washington, 63, broke his silence in an Instagram post on Saturday, Oct. 3, announcing that his wife of 29 years, Jenisa Washington, had died 16 months prior.
"Yes…the rumors are true. My dear wife of 29 years collapsed suddenly on May 31, 2025 and passed away on June 9, 2025. It came as a huge shock to me and our entire family," he wrote. "She succumbed to a massive hemorrhagic stroke and never recovered."
A hemorrhagic stroke happens "when a blood vessel in the brain bursts, causing bleeding (hemorrhage) in or around the brain," according to the National Library of Medicine's MedlinePlus. The pressure from the bleeding damages brain tissue, causing brain cells to start dying within minutes.
"Listen, y'all…some headaches are not just headaches or migraines, they can be much worse and a warning sign," Washington continued. "Get a brain scan if you can and take those headaches seriously."

#brain #wife #years #hemorrhagic
o8Vu168zab6ytrU
2 months ago
A home Medicaid excludes from **** et tests during life becomes fully exposed to estate recovery after death, potentially consuming most of an inheritance.
Transfers of a home within 60 months of a Medicaid application trigger a penalty period, and a stroke can eliminate the legal capacity needed to act.
Penalty-free exceptions exist, including spousal transfer, caregiver-child, and protected-relative rules, but qualifying circumstances must be in place well before a crisis.
Two retirees, same $1 million, same 4% rule, buy one finished with $1.4 million, the other hit $0 in 12 years. Our free reader guide explains the flaw that separated them, and the income-first method built to avoid it.
An 82-year-old widower has a stroke. From the hospital he moves to rehabilitation, then to permanent nursing-home care. His paid-off house is worth $340,000. His daughter asks the elder-law attorney whether they can deed her the house or drop it into an irrevocable trust before Medicaid pays a dime. The answer is the one no family wants to hear: probably not, because Dad no longer has the capacity to sign, and his durable power of attorney authorizes bill payment but not gifts or trust transfers.

#home #stroke #free
buonDZVsoc4rdUrf
2 months ago
On September 8, 2026, CNBC reported that Novartis' failed pelacarsen trial has raised the stakes for rival experimental cholesterol drugs from Amgen Inc. (NASDAQ:AMGN) and Eli Lilly and Company (NYSE:LLY), both of which are racing to prove that lowering lipoprotein(a), or Lp(a). It can meaningfully reduce heart attacks and strokes.
Analysts said Amgen's olpasiran faces the clearest negative read-through given its similar trial design. Lilly's lepodisiran is being tested in a broader patient population that could limit how directly Novartis' failure applies. It is also described as less material to Lilly's overall valuation than pelacarsen was for Novartis.
Copyright: stocking / 123RF Stock Photo
Amgen Inc. (NASDAQ:AMGN) and Eli Lilly and Company (NYSE:LLY) could still succeed where Novartis failed. Pelacarsen's failure does not establish that lowering Lp(a) cannot reduce cardiovascular events. **** ysts noted that Novartis' trial faced a high statistical hurdle and that Amgen's olpasiran and Lilly's lepodisiran have produced stronger Lp(a) reductions in earlier studies. Both companies also continue testing their drugs in specific patient populations with high Lp(a). It leaves room for their trials to produce different outcomes from Novartis' study.
Lilly's lepodisiran faces a less direct read-through than Amgen's olpasiran. **** ysts view Amgen's olpasiran as the closest comparison to pelacarsen because the programs use similar trial designs. Lilly's lepodisiran is being tested in an overall patient population. It could make Novartis' failure less directly applicable. **** ysts also view lepodisiran as less material to Lilly's overall valuation than pelacarsen was to Novartis. It reduces the potential financial impact of an unsuccessful outcome.

#lepodisiran #less
fixggj
2 months ago
Brian Ortega has pulled out of his scheduled UFC 331 bout against Renato Moicano with an injury.
'T-City' has endured harship in recent years. The 35-year-old has only managed five fights in the last five years, averaging one per year. But it isn't just his activity that has been slacking. His last win came in early 2024, which is his lone victory in five. Now out of the rankings and looking to move up a division, Ortega needed a stroke of good luck to come his way. That hasn't happened; in fact, bad luck seems to be looming overhead.
After falling out of the fight due to injury in March, Brian Ortega hoped a rescheduled clash against Renato Moicano would go smoothly. But just days ahead of his proposed appearance at UFC 331, injury strikes again.
While classified as an undisclosed injury, a picture has surfaced online that potentially shows the true cause. An image of Ortega with a significant cut and swelling above his left eye has been
With days to prepare for an opponent, Renato Moicano has been removed from the Los Angeles card entirely.

#renato #brian #years #last
tinywox
2 months ago
Amgen Inc. (NASDAQ:AMGN) shed roughly $12 billion in market value after hours on September 4, 2026. The stock declined by about 5% to $415. The reason, as strange as it sounds, is a drug it does not own. Novartis announced that pelacarsen, an Lp(a)-lowering therapy, missed its Phase 3 cardiovascular-outcomes trial, Lp(a)HORIZON. And since Amgen's late-stage ******* et olpasiran relies on the same biological premise, investors immediately marked down Amgen on the negative read-through.
The result strikes at a premise rather than at a product. Pelacarsenhad lowered Lp(a) by roughly 80% in earlier studies. In Lp(a)HORIZON, Novartis said pelacarsen substantially lowered Lp(a), but it still failed to reduce the composite of cardiovascular death, heart attack, stroke, and urgent revascularization. It still could not reduce the composite of cardiovascular death, heart attack, stroke, and urgent revascularization. And now the entire hypothesis that lowering Lp(a), a genetic cardiovascular risk factor, actually cuts events, is being directly challenged. Olpasiran is built on the same hypothesis, leading to the repricing of odds as soon as pelacarsen's data were out.
Amgen's olpasiran, an siRNA, lowered Lp(a) by more than 95% at certain doses in Phase 2, compared with reductions of roughly 80% for pelacarsen in earlier studies. The bull case is that this deeper reduction could help olpasiran deliver better cardiovascular outcomes.. The bull case is that this 15% will help Amgen to make a deeper cut and deliver results. While biologically possible, the Lp(a)HORIZON trial provided no evidence that a clinical threshold exists above an 80% reduction. The topline Phase 3 announcement did not establish that deeper Lp(a) lowering would have produced a cardiovascular benefit. It is therefore appropriate to say that the miss lowered olpasiran's probability of success rather than pretending it is irrelevant. Eli Lilly's lepodisiran is running the same deep-reduction experiment, so the hypothesis will be tested with or without Amgen.
Amgen is not an Lp(a) pure-play. MariTide in obesity, Repatha in cholesterol, and Tezspire in asthma drive more value for the company, and this diversification creates a cushion for the stock, although the selloff ultimately became much larger than the initial 5% after-hours reaction. Positioning has stayed calm since the beginning of 2026. Insider Monkey data shows 66 hedge funds held AMGN in the second quarter of 2026, up slightly from 65 in the first. Short interest, on the other hand, sits at just 2.4% of float, reflecting minimal bets against the stock in the market.

#horizon #pelacarsen
packEt
2 months ago
At the Solheim Cup, we watched pros do something difficult that a lot of average golfers attempt, too: play team golf. It's different from typical stroke play, or even one-on-one match play events. Pros, like the test of us, usually play their own ball. But in the Netherlands, they had to play with a partner in foursomes and four-ball. It's a serious change from what they're used to.
Making that shift from playing your own ball to playing a team format might be something you struggle with, too. We talked to Megan Johnston, a Golf Digest Best Young Teacher at Big Cedar who played on the Northern Ireland junior team with Solheim Cup standout Leona Maguire, about how average players can more seamlessly make the transition into team play.
"The biggest adjustment for the average golfer is realizing that the goal of the format may not be to shoot your lowest individual score," Johnston explains. "In four-ball, foursomes or a scramble, you're making decisions based on what your team needs. That changes everything—from club selection, to risk management, to how aggressive you should be at the right times."
This is how Johnston says you should think about these two different team formats.
Four-ball

#play #average #pros
sitgng6
2 months ago
Update morning 9/12: Ben Shelton outlasted fellow American Frances Tiafoe in the all-American semifinal to set up a dramatic men's final vs. top-seeded German Alexander Zverev on Sunday afternoon. Zverev has had quite an easy draw to the final, and he'll be the favorite to win his second major this year. Shelton's big serve will test him, and it will be on Shelton to hit competitive backhands to match strokes with Zverev, who also won the French Open. Meanwhile, the women's final between No. 1 seed Aryna Sabalenka vs. No. 2 seed Elena Rybakina should be a banger, and that kicks off in just a few hours.
Update late night 9/10: It will be No. 1 seed Aryna Sabalenka vs. No. 2 seed Elena Rybakina for the women's ****** le at the 2026 US Open on Saturday afternoon. The men take the spotlight on Friday with an all-American semifinal between Ben Shelton and Frances Tiafoe, plus No. 1 seed Alexander Zverev vs. unseeded Karen Khachanov.
The 2026 US Open is down to the Final Four, and both the men's and women's draws have produced some fantastic matchups. It's been 23 years since an American man won a tennis Grand Slam, but there are two U.S. natives facing off against each other in the semifinals — on the 25th anniversary of 9/11, no less. The women's draw went straight chalk with the top four seeds advancing to the semis, promising to bring fans the highest level of tennis possible.
The women's semifinals both take place on Thursday, September 10. Top-seeded masher Aryna Sabalenka takes on American No. 3 seed Jessica Pegula to open play at 7 p.m. ET at Arthur Ashe. Sabalenka looked to be on the brink of a meltdown in the quarterfinals against Wimbledon champ Linda Nosková, but she dug deep to win the match and stay alive. Sabalenka is the biggest hitter on tour, but she's been in a slump in 2026 without a major championship. She has already lost her world No. 1 ranking after the tournament, but she won't care if she can win her fifth major and third straight US Open ****** le. The 32-year-old Pegula is enjoying a late career peak, and she's still chasing her first Grand Slam. Pegula's steady nature could be an advantage against the more emotional Sabalenka.
Elena Rybakina faces American Coco Gauff in the night cap. Rybakina is the No. 2 seed in this tournament, but she will surpass Sabalenka for the world No. 1 ranking when it's over regardless of what happens. At 27, Rybakina is the second-oldest woman to ever ascend to world No. 1 in the rankings for the first time. Gauff will be the fan favorite. She was not at her top level in her quarterfinal victory over Mirra Andreeva, but she still got the job done to advance. Gauff beat Sabalenka in the 2023 US Open final and the 2025 French Open final. She's seeking her third major at age-22.

#final
vcTlD
2 months ago
Royalty Pharma plc (NASDAQ:RPRX) disclosed that pelacarsen failed the Phase 3 Lp(a)HORIZON cardiovascular-outcomes trial conducted by Novartis AG (NYSE:NVS). The randomized, double-blind study enrolled 8,323 patients with elevated lipoprotein(a), or Lp(a), and established cardiovascular disease.
Pelacarsen lowered Lp(a), but the study did not meet its primary endpoint of reducing cardiovascular events compared with placebo in the overall population. The endpoint combined cardiovascular death, nonfatal heart attack, nonfatal stroke, and urgent coronary revascularization requiring hospitalization. Complete results have not yet been presented.
Royalty Pharma plc (NASDAQ:RPRX) provided Ionis Pharmaceuticals, Inc. (NASDAQ:IONS) with $500 million in January 2023. The transaction allocated $150 million to pelacarsen royalties and $350 million to Spinraza royalties. The clinical failure shifts the financial focus from uncertain pelacarsen upside to recovery through Spinraza.
Royalty Pharma plc (NASDAQ:RPRX) acquired 25% of the Spinraza royalties received by Ionis Pharmaceuticals, Inc. (NASDAQ:IONS) through 2027. That share increases to 45% in 2028 on Spinraza annual sales of up to $1.5 billion.
Following the HORIZON result, the Spinraza interest will revert after aggregate payments to Royalty Pharma plc (NASDAQ:RPRX) reach $550 million, equal to 1.1 times the original funding. Management expects the structure to recover the entire investment and generate a modest positive return despite the clinical failure.

#royalty #pharma #cardiovascular #horizon
WnyFpAl9mlk
2 months ago
Luke Evans revealed that Tim Curry responded to his letter while the actor was seriously ill. Evans recalled Curry's response during a recent appearance. The actor also shared the last impact Curry had on his career.
Luke Evans reflected on his relationship with Tim Curry and shared how he responded to his letter shortly before his death.
During the Toronto International Film Festival, Luke Evans spoke to Entertainment Weekly and recalled Curry, saying, "He was very appreciative. I think he was very sick when he got the letter — he was struggling a lot — and I've spoken to his publisher since. He struggled to speak and talk, so I think he was really in a bad place, but what a legacy."
Evans shared that fellow actor Tim Curry responded to a heartfelt letter he sent to the actor shortly before Curry's death at the age of 80.
The Rocky Horror Picture Show star died of coronary artery disease. Curry also had a history of stroke and kidney cancer. These conditions were made public but were not the underlying cause of his death.

#LUKE #actor
ojcvrqorctzwj
2 months ago
Paola of Belgiumturns 89 this September 11: the Belgian press isn't publishing big special features on her, and so far the official channels also haven't marked the day with a new photo or a public gesture, as they tend to do when it's a milestone birthday. It's been a while since the woman who was queen consort for two decades stepped into the background; she suffered a stroke in 2018, from which she recovered, and now lives a quiet life between Belgium and the south of France.
Her public appearances are now rare; here she is with her husband, Albert II, and the current monarchs, her son, Philippe of the Belgians, and his wife, Queen Mathilde. The picture was taken in 2023 during National Day. (@ Patrick van Katwijk)
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#september #philippe
cl1ck2202
2 months ago
On August 27, AstraZeneca PLC (NYSE:AZN) and Amgen Inc. (NASDAQ:AMGN) scored a shared clinical victory. Positive high-level results from the Phase III CROSSING trial showed that their co-developed severe asthma drug, TEZSPIRE, achieved statistically significant and clinically meaningful improvements across both co-primary endpoints, histologic remission and the frequency/severity of dysphagia, and all key secondary endpoints at week 24 in patients with eosinophilic esophagitis. These benefits were sustained through week 52 across both tested doses, accompanied by a safety profile consistent with its approved indications. While CROSSING highlights their joint R&D success, a closer look at their standalone financial performance reveals distinct growth trajectories.
Both pharmaceutical giants delivered solid Q2 2026 results, but AstraZeneca is showing stronger overall financial momentum. AstraZeneca PLC (NYSE:AZN)'s Q2 revenue increased 6% year over year to $15.38 billion, supported by its Oncology franchise, which grew 18% in H1 to $14.12 billion, and its Rare Disease portfolio, which increased 13%. Core EPS rose 21% to $2.63, beating expectations, while management reaffirmed its full-year 2026 outlook for mid-to-high single-digit revenue growth and low double-digit Core EPS growth.
Amgen Inc. (NASDAQ:AMGN) reported Q2 revenue of $10.1 billion, up 10% year over year, while non-GAAP EPS increased 4% to $6.29. Although its key growth products advanced 26%, mature products faced significant biosimilar pressure, with Prolia revenue declining 32% and XGEVA falling 34%. Amgen nevertheless raised its 2026 revenue guidance midpoint to $39.4 billion.
Overall, AZN holds the financial edge due to stronger EPS growth, broader portfolio momentum, and less exposure to the biosimilar erosion affecting AMGN's mature products.
Amgen's bull case is supported by robust growth in key products, which increased 26%, and $3.5 billion in Q2 free cash flow, providing substantial capital flexibility. Wells Fargo raised its Amgen price target to $435 from $400 on September 4, citing potential upside from HORIZON and pipeline ****** ets such as olpasiran. New Phase III VESALIUS-CV data also showed Repatha reduced the risk of death by 20% in high-risk adults without a prior heart attack or stroke, with heart attack risk reductions emerging as early as six months. However, accelerating biosimilar competition affecting legacy franchises such as Prolia and XGEVA remains a key risk to sustained margin expansion.

#revenue #astrazeneca #increased #products

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