16 hours ago
Royalty Pharma plc (NASDAQ:RPRX) disclosed that pelacarsen failed the Phase 3 Lp(a)HORIZON cardiovascular-outcomes trial conducted by Novartis AG (NYSE:NVS). The randomized, double-blind study enrolled 8,323 patients with elevated lipoprotein(a), or Lp(a), and established cardiovascular disease.
Pelacarsen lowered Lp(a), but the study did not meet its primary endpoint of reducing cardiovascular events compared with placebo in the overall population. The endpoint combined cardiovascular death, nonfatal heart attack, nonfatal stroke, and urgent coronary revascularization requiring hospitalization. Complete results have not yet been presented.
Royalty Pharma plc (NASDAQ:RPRX) provided Ionis Pharmaceuticals, Inc. (NASDAQ:IONS) with $500 million in January 2023. The transaction allocated $150 million to pelacarsen royalties and $350 million to Spinraza royalties. The clinical failure shifts the financial focus from uncertain pelacarsen upside to recovery through Spinraza.
Royalty Pharma plc (NASDAQ:RPRX) acquired 25% of the Spinraza royalties received by Ionis Pharmaceuticals, Inc. (NASDAQ:IONS) through 2027. That share increases to 45% in 2028 on Spinraza annual sales of up to $1.5 billion.
Following the HORIZON result, the Spinraza interest will revert after aggregate payments to Royalty Pharma plc (NASDAQ:RPRX) reach $550 million, equal to 1.1 times the original funding. Management expects the structure to recover the entire investment and generate a modest positive return despite the clinical failure.
#royalty #pharma #cardiovascular #horizon
Pelacarsen lowered Lp(a), but the study did not meet its primary endpoint of reducing cardiovascular events compared with placebo in the overall population. The endpoint combined cardiovascular death, nonfatal heart attack, nonfatal stroke, and urgent coronary revascularization requiring hospitalization. Complete results have not yet been presented.
Royalty Pharma plc (NASDAQ:RPRX) provided Ionis Pharmaceuticals, Inc. (NASDAQ:IONS) with $500 million in January 2023. The transaction allocated $150 million to pelacarsen royalties and $350 million to Spinraza royalties. The clinical failure shifts the financial focus from uncertain pelacarsen upside to recovery through Spinraza.
Royalty Pharma plc (NASDAQ:RPRX) acquired 25% of the Spinraza royalties received by Ionis Pharmaceuticals, Inc. (NASDAQ:IONS) through 2027. That share increases to 45% in 2028 on Spinraza annual sales of up to $1.5 billion.
Following the HORIZON result, the Spinraza interest will revert after aggregate payments to Royalty Pharma plc (NASDAQ:RPRX) reach $550 million, equal to 1.1 times the original funding. Management expects the structure to recover the entire investment and generate a modest positive return despite the clinical failure.
#royalty #pharma #cardiovascular #horizon
20 hours ago
Luke Evans revealed that Tim Curry responded to his letter while the actor was seriously ill. Evans recalled Curry's response during a recent appearance. The actor also shared the last impact Curry had on his career.
Luke Evans reflected on his relationship with Tim Curry and shared how he responded to his letter shortly before his death.
During the Toronto International Film Festival, Luke Evans spoke to Entertainment Weekly and recalled Curry, saying, "He was very appreciative. I think he was very sick when he got the letter — he was struggling a lot — and I've spoken to his publisher since. He struggled to speak and talk, so I think he was really in a bad place, but what a legacy."
Evans shared that fellow actor Tim Curry responded to a heartfelt letter he sent to the actor shortly before Curry's death at the age of 80.
The Rocky Horror Picture Show star died of coronary artery disease. Curry also had a history of stroke and kidney cancer. These conditions were made public but were not the underlying cause of his death.
#LUKE #actor
Luke Evans reflected on his relationship with Tim Curry and shared how he responded to his letter shortly before his death.
During the Toronto International Film Festival, Luke Evans spoke to Entertainment Weekly and recalled Curry, saying, "He was very appreciative. I think he was very sick when he got the letter — he was struggling a lot — and I've spoken to his publisher since. He struggled to speak and talk, so I think he was really in a bad place, but what a legacy."
Evans shared that fellow actor Tim Curry responded to a heartfelt letter he sent to the actor shortly before Curry's death at the age of 80.
The Rocky Horror Picture Show star died of coronary artery disease. Curry also had a history of stroke and kidney cancer. These conditions were made public but were not the underlying cause of his death.
#LUKE #actor
9 days ago
British actor Tim Curry died of coronary artery disease, his spokesman has confirmed to the BBC.
The Rocky Horror Picture Show star died in his Los Angeles home on 25 August, aged 80.
In addition to the heart condition, Curry had a history of stroke and kidney cancer, which were significant conditions that contributed to his death, his spokesman said, citing a death certificate filed in Los Angeles County.
Stars of stage and screen paid tribute to the actor, who shot to fame as the lingerie-clad Dr Frank-N-Furter in the cult 1975 film The Rocky Horror Show.
After having a near-fatal stroke in 2012, the actor used a wheelchair. He shifted his focus to voice acting exclusively, expressing gratitude that the stroke resulted in paralysis rather than taking away his ability to speak.
#died #death
The Rocky Horror Picture Show star died in his Los Angeles home on 25 August, aged 80.
In addition to the heart condition, Curry had a history of stroke and kidney cancer, which were significant conditions that contributed to his death, his spokesman said, citing a death certificate filed in Los Angeles County.
Stars of stage and screen paid tribute to the actor, who shot to fame as the lingerie-clad Dr Frank-N-Furter in the cult 1975 film The Rocky Horror Show.
After having a near-fatal stroke in 2012, the actor used a wheelchair. He shifted his focus to voice acting exclusively, expressing gratitude that the stroke resulted in paralysis rather than taking away his ability to speak.
#died #death
10 days ago
Tim Curry's cause of death has been revealed to be coronary artery disease, according to documents from the Los Angeles County Department of Public Health reviewed by People.
The British actor died on Aug. 25 at the age of 80. The Rocky Horror Picture Show and It star reportedly had a history of kidney cancer and stroke. These conditions did not create an underlying cause that directly led to his death, though they were contributing factors. Curry did not undergo surgery to treat his cancer or stroke, which occurred in 2012.
More from Rolling Stone
Tim Curry Tributes Pour in From Co-Stars Carol Burnett, Rob Schneider, Michael McKean, More
Tim Curry, 'Rocky Horror Picture Show,' 'Clue,' and 'It' Star, Dead at 80
#horror #picture #star #cause
The British actor died on Aug. 25 at the age of 80. The Rocky Horror Picture Show and It star reportedly had a history of kidney cancer and stroke. These conditions did not create an underlying cause that directly led to his death, though they were contributing factors. Curry did not undergo surgery to treat his cancer or stroke, which occurred in 2012.
More from Rolling Stone
Tim Curry Tributes Pour in From Co-Stars Carol Burnett, Rob Schneider, Michael McKean, More
Tim Curry, 'Rocky Horror Picture Show,' 'Clue,' and 'It' Star, Dead at 80
#horror #picture #star #cause
10 days ago
Actor Tim Curry's cause of death was revealed one week after the beloved actor died on Tuesday, August 25.
According to People, documents obtained from the Los Angeles County Department of Public Health revealed that Curry died of coronary artery disease, a condition caused by the buildup of plaque in the arteries that supply blood to the heart.
In the report, it was stated that the document also listed a history of stroke and kidney cancer as other factors that contributed to Curry's death; however, they were not the underlying cause of death.
The document also states that no surgeries were performed for the coronary artery disease, nor for the actor's history of kidney cancer or the stroke he suffered over a decade before.
Tibrina Hobson/Getty Images
#coronary #document
According to People, documents obtained from the Los Angeles County Department of Public Health revealed that Curry died of coronary artery disease, a condition caused by the buildup of plaque in the arteries that supply blood to the heart.
In the report, it was stated that the document also listed a history of stroke and kidney cancer as other factors that contributed to Curry's death; however, they were not the underlying cause of death.
The document also states that no surgeries were performed for the coronary artery disease, nor for the actor's history of kidney cancer or the stroke he suffered over a decade before.
Tibrina Hobson/Getty Images
#coronary #document
10 days ago
Tim Curry's cause of death has been revealed eight days after his passing on Aug. 25.
According to documents obtained by People from the Los Angeles County Department of Public Health, the "Rocky Horror Picture Show" actor died of coronary artery disease. The report also cited his history of health issues including his 2012 stroke and kidney cancer. While these ailments contributed to his death they were not the underlying cause.
The actor died last week at his home in Toluca Lake, Los Angeles, 14 years after he suffered a paralyzing stroke. He maintained a presence in the public eye through the intervening years through fan conventions, social media and his 2025 memoir "Vagabond."
"Though widely known for his inimitable, flamboyant characters and colorful stage performances, his greatest legacies to those who knew him were his curious, expansive mind and generous, gentle heart, both of which remained open and filled with anticipation until his final breath," Curry's team shared in a statement last week.
More to come…
#angeles #death
According to documents obtained by People from the Los Angeles County Department of Public Health, the "Rocky Horror Picture Show" actor died of coronary artery disease. The report also cited his history of health issues including his 2012 stroke and kidney cancer. While these ailments contributed to his death they were not the underlying cause.
The actor died last week at his home in Toluca Lake, Los Angeles, 14 years after he suffered a paralyzing stroke. He maintained a presence in the public eye through the intervening years through fan conventions, social media and his 2025 memoir "Vagabond."
"Though widely known for his inimitable, flamboyant characters and colorful stage performances, his greatest legacies to those who knew him were his curious, expansive mind and generous, gentle heart, both of which remained open and filled with anticipation until his final breath," Curry's team shared in a statement last week.
More to come…
#angeles #death
10 days ago
We now have a cause of death for Rocky Horror Picture Show actor Tim Curry.
Documents from the Los Angeles County Department of Public Health obtained by People reveal Curry died of coronary artery disease. A history of stroke and kidney cancer were listed as other significant conditions that contributed to his death, but did not result in the underlying cause of death.
More from Deadline
Tim Curry Dies: 'The Rocky Horror Picture Show' Actor Was 80
Remembering Tim Curry: A Career in Photos
#curry #rocky #documents
Documents from the Los Angeles County Department of Public Health obtained by People reveal Curry died of coronary artery disease. A history of stroke and kidney cancer were listed as other significant conditions that contributed to his death, but did not result in the underlying cause of death.
More from Deadline
Tim Curry Dies: 'The Rocky Horror Picture Show' Actor Was 80
Remembering Tim Curry: A Career in Photos
#curry #rocky #documents
10 days ago
Actor Tim Curry's cause of death has been released a week after his death.
The actor's primary cause of death was coronary artery disease, People reported Sept. 2, citing the documents from the Los Angeles County Department of Public Health. Other contributing conditions were a history of stroke and kidney cancer.
Coronary heart disease is the most common type of heart disease in the U.S. Heart disease is the leading cause of death nationwide.
Curry, who is best known for his roles in "The Rocky Horror Picture Show" and "It," died Tuesday, Aug. 25, at the age of 80, his representative Sean Katz confirmed to USA TODAY.
"Tim Curry, the iconic actor and entertainer globally beloved for his dynamic contributions to the stage and screen, passed away peacefully at his home in Toluca Lake, Los Angeles," the statement read.
#cause #actor
The actor's primary cause of death was coronary artery disease, People reported Sept. 2, citing the documents from the Los Angeles County Department of Public Health. Other contributing conditions were a history of stroke and kidney cancer.
Coronary heart disease is the most common type of heart disease in the U.S. Heart disease is the leading cause of death nationwide.
Curry, who is best known for his roles in "The Rocky Horror Picture Show" and "It," died Tuesday, Aug. 25, at the age of 80, his representative Sean Katz confirmed to USA TODAY.
"Tim Curry, the iconic actor and entertainer globally beloved for his dynamic contributions to the stage and screen, passed away peacefully at his home in Toluca Lake, Los Angeles," the statement read.
#cause #actor
10 days ago
Tim Curry died of coronary artery disease, according to documents obtained by PEOPLE one week after the beloved actor died at 80 on Tuesday, Aug. 25
Los Angeles' public health department also listed a history of stroke and kidney cancer as other significant conditions that contributed to his death
Curry's manager confirmed news of his death with PEOPLE on Wednesday, Sept. 26, the day after he died
Tim Curry's cause of death has been revealed.
On Wednesday, Sept. 2 — eight days after The Rocky Horror Picture Show died at 80 on Tuesday, Aug. 25 — PEOPLE obtained documents from the Los Angeles County Department of Public Health that indicate Curry died of coronary artery disease. The public health department's document also listed a history of stroke and kidney cancer as other significant conditions that contributed to his death, but did not result in the underlying cause of Curry's death.
#Health #tuesday #angeles
Los Angeles' public health department also listed a history of stroke and kidney cancer as other significant conditions that contributed to his death
Curry's manager confirmed news of his death with PEOPLE on Wednesday, Sept. 26, the day after he died
Tim Curry's cause of death has been revealed.
On Wednesday, Sept. 2 — eight days after The Rocky Horror Picture Show died at 80 on Tuesday, Aug. 25 — PEOPLE obtained documents from the Los Angeles County Department of Public Health that indicate Curry died of coronary artery disease. The public health department's document also listed a history of stroke and kidney cancer as other significant conditions that contributed to his death, but did not result in the underlying cause of Curry's death.
#Health #tuesday #angeles
13 days ago
Kelly Osbourne is keeping her head up amid a trying few months.
In July of last year, the former The View personality lost her father Ozzy Osbourne, who died at 76 from a heart attack, his coronary artery disease and Parkinson's disease with autonomic dysfunction being contributing factors.
Shortly after, the former reality star split from her fiancé Sid Wilson, though her brother Jack Osbourne maintains she is now in a "happier place."
Kelly in London on August 27, 2026 (@ Max Cisotti/Dave Benett/Getty Im)
Jack, speaking with The Sun, shared that Kelly, who shares son Sidney, three, with her ex-fiancé, said: "Kelly's living her country life."
#osbourne #former #disease #shortly
In July of last year, the former The View personality lost her father Ozzy Osbourne, who died at 76 from a heart attack, his coronary artery disease and Parkinson's disease with autonomic dysfunction being contributing factors.
Shortly after, the former reality star split from her fiancé Sid Wilson, though her brother Jack Osbourne maintains she is now in a "happier place."
Kelly in London on August 27, 2026 (@ Max Cisotti/Dave Benett/Getty Im)
Jack, speaking with The Sun, shared that Kelly, who shares son Sidney, three, with her ex-fiancé, said: "Kelly's living her country life."
#osbourne #former #disease #shortly
2 months ago
Harvey Weinstein is facing another setback in his ongoing health battle.
The Oscar-winning producer and disgraced movie mogul was recently hospitalized for "heart and breathing issues," Weinstein's representative, Juda Engelmayer, confirmed to USA TODAY on Wednesday, July 1.
Engelmayer said Weinstein's medical ordeal was exacerbated by a case of pneumonia. He is currently recovering at Bellevue Hospital in New York City.
The Miramax cofounder has experienced a spate of health issues in recent years.
A November 2024 filing from one of Weinstein's lawyers listed medical problems such as chronic myeloid leukemia (bone marrow cancer), diabetes, coronary artery disease, obstructive sleep apnea, thyroid issues, obesity, high blood pressure and chronic back pain. The lawyer, Imran H. Ansari, accused Rikers Island Correctional Facility of having "failed to render proper medical treatment."
The Oscar-winning producer and disgraced movie mogul was recently hospitalized for "heart and breathing issues," Weinstein's representative, Juda Engelmayer, confirmed to USA TODAY on Wednesday, July 1.
Engelmayer said Weinstein's medical ordeal was exacerbated by a case of pneumonia. He is currently recovering at Bellevue Hospital in New York City.
The Miramax cofounder has experienced a spate of health issues in recent years.
A November 2024 filing from one of Weinstein's lawyers listed medical problems such as chronic myeloid leukemia (bone marrow cancer), diabetes, coronary artery disease, obstructive sleep apnea, thyroid issues, obesity, high blood pressure and chronic back pain. The lawyer, Imran H. Ansari, accused Rikers Island Correctional Facility of having "failed to render proper medical treatment."
3 months ago
We recently compiled a list of the 10 Best Weight Loss Drug Stocks to Buy in 2026. Amgen Inc. (NASDAQ:AMGN) is one of the best weight loss drugs on this list.
TheFly reported on June 16 that Mizuho ****** yst Salim Syed increased the price target for AMGN to $303 from $295 while maintaining a Neutral rating on the shares. The adjustment followed an update to the firm's valuation model after reviewing AMGN's first quarter results.
In separate news, on June 7, Amgen Inc. (NASDAQ:AMGN) presented new clinical findings at the American Diabetes ****** ociation (ADA) 86th Scientific Sessions, highlighting its efforts to address cardiovascular risks among people with cardiometabolic conditions. The company shared Phase 3 VESALIUS-CV subgroup data evaluating Repatha in 6,002 high-risk diabetes patients with elevated LDL-C levels who had not previously experienced a heart attack or stroke.
The ****** ysis showed that Repatha, used alongside statins or other LDL-C-lowering treatments, lowered the likelihood of major cardiovascular events, including coronary heart disease death, heart attack, or ischemic stroke, by 29% compared with placebo. The treatment also demonstrated a 21% reduction in a broader cardiovascular outcome that included ischemia-related revascularization. Patients receiving Repatha achieved a median LDL-C level of 45 mg/dL, compared with 106 mg/dL among those receiving placebo.
Amgen Inc. (NASDAQ:AMGN) is a global biotech company gaining investor attention in the weight-loss market through MariTide, an experimental obesity drug in Phase 3 trials. With potential monthly dosing and strong weight-loss results, MariTide could become a major competitor in the growing obesity treatment ****** e.
TheFly reported on June 16 that Mizuho ****** yst Salim Syed increased the price target for AMGN to $303 from $295 while maintaining a Neutral rating on the shares. The adjustment followed an update to the firm's valuation model after reviewing AMGN's first quarter results.
In separate news, on June 7, Amgen Inc. (NASDAQ:AMGN) presented new clinical findings at the American Diabetes ****** ociation (ADA) 86th Scientific Sessions, highlighting its efforts to address cardiovascular risks among people with cardiometabolic conditions. The company shared Phase 3 VESALIUS-CV subgroup data evaluating Repatha in 6,002 high-risk diabetes patients with elevated LDL-C levels who had not previously experienced a heart attack or stroke.
The ****** ysis showed that Repatha, used alongside statins or other LDL-C-lowering treatments, lowered the likelihood of major cardiovascular events, including coronary heart disease death, heart attack, or ischemic stroke, by 29% compared with placebo. The treatment also demonstrated a 21% reduction in a broader cardiovascular outcome that included ischemia-related revascularization. Patients receiving Repatha achieved a median LDL-C level of 45 mg/dL, compared with 106 mg/dL among those receiving placebo.
Amgen Inc. (NASDAQ:AMGN) is a global biotech company gaining investor attention in the weight-loss market through MariTide, an experimental obesity drug in Phase 3 trials. With potential monthly dosing and strong weight-loss results, MariTide could become a major competitor in the growing obesity treatment ****** e.
3 months ago
Amgen Inc. (NASDAQ:AMGN) is one of the
7 Best Longevity Stocks to Buy Now.
On June 7, 2026, Amgen Inc. (NASDAQ:AMGN) announced new data at the American Diabetes ****** ociation 86th Scientific Sessions, including Phase 3 VESALIUS-CV subgroup results for Repatha in patients with high-risk diabetes and elevated LDL-C without prior heart attack or stroke. In an ****** ysis of 6,002 patients, Repatha, when added to statins or other LDL-C-lowering therapies, reduced the risk of the composite primary endpoint of coronary heart disease death, myocardial infarction, or ischemic stroke by 29% compared with placebo. Repatha also reduced the risk of a second composite primary endpoint that included ischemia-driven revascularization by 21%.
On June 5, 2026, Goldman Sachs lowered the firm’s price target on Amgen Inc. (NASDAQ:AMGN) to $389 from $425 and maintained a Buy rating on the shares. Goldman Sachs adjusted its model after Amgen disclosed in its Q1 earnings that the IRS audit for 2016 to 2018 had escalated into a formal dispute, with the company receiving a notice of proposed adjustment.
Earlier in June, Amgen announced that the European Commission granted marketing authorization for Imdylltra as a monotherapy for adults with extensive-stage small cell lung cancer who require systemic therapy after disease progression on or after first-line platinum-based chemotherapy.
7 Best Longevity Stocks to Buy Now.
On June 7, 2026, Amgen Inc. (NASDAQ:AMGN) announced new data at the American Diabetes ****** ociation 86th Scientific Sessions, including Phase 3 VESALIUS-CV subgroup results for Repatha in patients with high-risk diabetes and elevated LDL-C without prior heart attack or stroke. In an ****** ysis of 6,002 patients, Repatha, when added to statins or other LDL-C-lowering therapies, reduced the risk of the composite primary endpoint of coronary heart disease death, myocardial infarction, or ischemic stroke by 29% compared with placebo. Repatha also reduced the risk of a second composite primary endpoint that included ischemia-driven revascularization by 21%.
On June 5, 2026, Goldman Sachs lowered the firm’s price target on Amgen Inc. (NASDAQ:AMGN) to $389 from $425 and maintained a Buy rating on the shares. Goldman Sachs adjusted its model after Amgen disclosed in its Q1 earnings that the IRS audit for 2016 to 2018 had escalated into a formal dispute, with the company receiving a notice of proposed adjustment.
Earlier in June, Amgen announced that the European Commission granted marketing authorization for Imdylltra as a monotherapy for adults with extensive-stage small cell lung cancer who require systemic therapy after disease progression on or after first-line platinum-based chemotherapy.
