Xenon Pharmaceuticals (XENE) shares crashed on Friday after the biopharmaceutical firm said it has paused new patient enrollment in its clinical trials evaluating azetukalner. As investors responded to the setback involving XENE's lead drug candidate for major depressive disorder, its relative strength index (RSI) slipped into the early teens, indicating extremely oversold conditions.
Following today's decline, Xenon Pharmaceuticals stock is trading nearly 40% below its year-to-date high.
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#xene #following #America

Biohaven (BHVN) stock plummeted Thursday after the company paused enrollment in a midstage study of its seizure treatment due to safety concerns.
The Food and Drug Administration is now requiring Biohaven to ***** s the potential for human toxicity from a metabolite in the drug, opakalim. Opakalim is in testing as a treatment for focal onset seizures. But, in rats, it proved toxic.
Dosing is still ongoing. But the rodent toxicity setback likely delays potential regulatory approval. That's a boon for Xenon Pharmaceuticals (XENE), which is in late-stage testing with its drug, azetukalner. Both drugs work by opening potassium channels in the nervous system to calm overactive brain cells.
On the stock market today, Biohaven stock dropped 14.7% to 12.79. Shares fell below their 21-day and 50-day moving averages on the news, MarketSurge shows. Xenon stock slid a fraction to 58.80.
To ask for FDA approval, Biohaven will need the results of studies called RISE-2 and RISE-3. The hold was placed on the former, but the latter is still ongoing. The company expects to have the results from RISE-3 later this year.

#toxicity

Gerard Piqué has said his final goodbye to his paternal grandmother, Lina Rovira Montsant, who has passed away at the age of 102. After the wake, which took place at the Sant Guim de Freixenet funeral home between 5:00 p.m. and 8:30 p.m. last Tuesday, the family gathered for a funeral mass at the Sagrat Cor de Sant Guim church, in Lleida. Around noon, relatives and close friends of Lina arrived, including Gerard and his girlfriend, Clara Chía.
Gerard Piqué is mourning the death of his paternal grandmother, Lina Rovira Montsant, who died at 102 as his family prepares for her funeral in Spain. (@ Getty Images)
The former soccer player arrived with his partner, who has been his biggest support during this very delicate moment for Gerard Piqué and his family. Together with the athlete's parents, Joan Piqué and Montserrat Bernabéu, they walked in the funeral procession behind the car carrying the casket to the church. The photos obtained by ¡HOLA! Spain show Gerard Piqué with his head down and visibly affected, never letting go of Clara's hand, as she stayed close to him at all times.
Gerard Pique with girlfriend Clara Chia during a romantic getaway in Venice, Italy, (@ Backgrid UK/The Grosby Group)
Clara, who turned 27 in April, kept a low profile, quietly standing by as the pillar Gerard Piqué leans on and offering comfort to the family in this sad farewell. She attended the funeral in a simple look made up of a short-sleeved black T-shirt and wide-leg beige pants, paired with black ballet flats and oversized sunglasses. The former athlete, for his part, wore a white polo shirt, wide-leg black pants and matching loafers.

#montsant #sant

While it seems that Democrats and Republicans can't agree on much of anything these days, there's at least one common enemy that's bringing both sides of the aisle together: data centers. Representatives on both sides of the aisle are increasingly pushing back against hyperscalers who are developing massive data center campuses on local energy grids, driving up energy demand and therefore causing electricity prices to skyrocket for everyone, whether they benefit from the artificial intelligence boom or not.
The Trump administration has attempted to resolve the issue by pushing the tech sector to provide its own energy sources to power its rapidly proliferating data centers. But while the legislation ostensibly pushes the responsibility of energy buildout – and the money to support it – back onto the tech firms responsible for skyrocketing energy demand rates in the first place, there is some concern that the policy may yield some considerable and costly unintended consequences.
Trump "essentially envisions a bespoke new power system built in parallel to the existing one," argues a recent op-ed from the energy editor of non-partisan news outlet Semafor. By inviting Big Tech to build its own energy infrastructure, policymakers are inviting the private sector to create a shadow grid that operates outside of the regulations that govern our standard electricity grids, and the oversight mechanisms that ensure compliance with other policy measures, such as environmental protections.
Plus, by encouraging Big Tech to invest in its own energy infrastructure, the country is missing out on a major opportunity to encourage much-needed investment in its own aging grid at a time when more resilience and greater transmission infrastructure is sorely needed. "Most of today's cost pressure is coming from transmission, distribution, and system readiness, not energy supply," Brandon Owens, a grid expert and founder of advisory platform AIxEnergy, was quoted by Politico last week. "Those costs remain even if a data center self-supplies generation."
Despite these concerns, Big Tech is pushing ahead with some truly gargantuan energy infrastructure projects, most of which are being developed in tandem with sprawling data center campuses. Amazon is currently building a gas-fired power plant in Texas that is set to become the single-biggest source of power-related emissions in the entire United States. And just this week, Nvidia announced that it would team up with ****** an's SoftBank and the United States government to build the country's largest fossil-fuel plant to power an OpenAI project in Ohio.

#Trump

Matchday 2 of the Clausura Tournament sees Boca Juniors and Estudiantes de La Plata face off today.
The venue? Unusual, because today the xeneize are playing at home at Huracán's Tomás Adolfo Ducó stadium due to the poor condition of La Bombonera.
Both teams line up as follows:
Boca Juniors: Montero; Lozano, Di Lollo, Pellegrino, Blanco; Delgado, Paredes, Ascacibar; Aranda, Flores and Merentiel.

#boca #clausura #tournament #hurac

Long-term contract rates businesses pay to move air freight are expected to rise 5% to 15% this year, instead of retreating, because the resumption of hostilities between Iran and the United States is once again reducing airline capacity through the critical Middle East corridor, freight ***** ytics firm Xeneta said in a market outlook published on Friday.
Xeneta's initial forecast at the start of the year was for contract rates to fall 5% to 10% in 2026.
Strong demand for semiconductors and AI-related hardware helped push air cargo demand to 7% year-over-year growth in June. AI technology represents about 10% of total air cargo volume. The June volume growth was well ahead of expectations and supply, which grew 3% with the return of capacity suspended by the Middle East disruption. The demand-supply imbalance pushed aircraft utilization up 3 points to 62%, which influenced the higher rates.
But market dynamics since Xeneta's monthly report on July 2 are quickly changing again after the United States and Iran broke a shaky ceasefire last week.
The start of the Iran war on Feb. 28 immediately forced more than 12% of global air cargo capacity — in passenger belly holds and freighter aircraft — out of service because of airspace and airport closures, flight cancellations and reduced frequencies, and longer transit times for rerouting to avoid war risk. Initial capacity reductions were close to 20%, according to consultancy Rotate.