Week 1 of the CFB season is full of non-conference matchups between P4 teams and the dregs of FBS or FCS. Few teams are taking risks this season, at least in their season opener, in order to avoid putting an L on their resume for the CFP committee later in the year. As a result, it's difficult to find many games with single-digit spreads. Nonetheless, there should be some entertaining games and we'll learn a lot some of the relative strengths and weaknesses of the contenders.
As always, the lines come from the FanDuel Sports Book.
Fresno St @ USC (-22.5)
The Trojans are one of the few teams in this article who have actually taken the field already in 2026. Jayden Maiava beautifully orchestrated Lincoln Riley's offense to a 35-3 lead before taking their foot off the gas against San Jose St. Matt Entz will debut as Fresno's new HC. For what it's worth, the former North Dakota St. HC was my least favorite Bison coach of the National Championship era, so I'm not sold that he'll be the long-term answer for the Bulldogs.
USC 35 – Fresno St. 14

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