Joe Manganiello has opened up about his years-long health battle ahead of the release of his memoir, Bloodlines, and shared how dealing with an ongoing illness led him back to the past.
The Magic Mike actor has not appeared at a public event since August 2025, when he was seen at The Wizard of Oz premiere at the Sphere in Las Vegas, and looked entirely unrecognizable on the cover of his memoir, pointing to his ill health.
In the book, Joe will speak on "a previously undisclosed health ordeal – marked by multiple near-death experiences and medical crises – that led him beyond medicine and into a remarkable, globe-spanning quest that revealed answers about his ancestry, inherited trauma, and the deeper histories we carry," as per the press release.
The 49-year-old shared that his health quickly declined "without warning" as "a cascade of autoimmune-related illnesses attacked his skin, thyroid, eyes, lungs, and digestive system". He added that he was constantly "plagued by chronic pain" and experienced a "life-saving organ amputation, existential crisis, and a prolonged fight for survival that left doctors with few answers and no clear explanation".
As he searched for answers, Joe encountered everything from "shamans, pagan rituals, ancient myths, long-lost family records and the rebirth of his own spirituality," as per the book's synopsis.